Eliminating Damaged Mitochondria Before They Worsen Chronic Inflammation

NLRP3 inflammasome promotes inflammation because it triggers the release of two very potent pro-inflammatory molecules called cytokines: interleukin (IL)-1β and IL-18. According to Karin, there are existing drugs that can block IL-1β, but not IL-18. ChoK inhibitors, his team found, can reduce both cytokines. "There are several diseases, including lupus and osteoarthritis, whose treatment will likely require dual inhibition of both IL-1β and IL-18," Karin said. https://www.technologynetworks.com/cell-science/news/eliminating-damaged-mitochondria-before-they-worsen-chronic-inflammation-318116?utm_campaign=NEWSLETTER_TN_Breaking%20Science%20News&utm_source=hs_email&utm_medium=email&utm_content=71697539&_hsenc=p2ANqtz-8EmUggIpqWRO0S1rVWzismAGs96a8HyzXzUK69xNV-Hx5iWq4Uhys8VZ_MigNqS__DATT6FwkKhCImFjtIJZlYyqIBPw&_hsmi=71697539