Gene Linked to Appetite Regulation Offers Obesity Insights

"We had identified a group of severely obese children carrying rare genetic variants in the SRC-1 gene," said co-corresponding author Dr. I. Sadaf Farooqi, professor of metabolism and medicine in the Department of Clinical Biochemistry at the University of Cambridge and Wellcome Trust Principal Research Fellow. Working together, Xu, Sadaf Farooqi and their colleagues found that many of the SRC-1 variants in the obese children produced dysfunctional proteins that disrupted the normal function of SRC-1. On the other hand, SRC-1 variants in healthy individuals did not disrupt SRC-1 function. Furthermore, mice genetically engineered to express one of the human SRC-1 genetic variants found in obese children ate more and gained weight. https://www.technologynetworks.com/genomics/news/gene-linked-to-appetite-regulation-offers-obesity-insights-318199?utm_campaign=NEWSLETTER_TN_Breaking%20Science%20News&utm_source=hs_email&utm_medium=email&utm_content=71749895&_hsenc=p2ANqtz-_uzQihMVJEqv30s6xeIjNbHPuahcVNPPO9xfI4LmKpS_uBd4m6xXOJdFnYdXTZIVu6AOyi2ny3NbxPTh-JTGZQzmXG_Q&_hsmi=71749895