Elevated B.M.I. and numerous blood indications of metabolic risk closely matched higher gene scores, strongly suggesting that higher B.M.I. alone causes the increase in cardiovascular risk factors independent of fatty food consumption, exercise, smoking and other variables.
http://well.blogs.nytimes.com/2014/12/12/weight-gain-carries-risks-no-matter-your-weight/?ref=health&_r=0
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