Acute Exercise May Affect Expression Of Insulin Resistance Genes In Skeletal Muscles Of Women With PCOS, Research Suggests.

“Acute exercise appeared to affect the expression of insulin resistance genes in the skeletal muscles of women with polycystic ovary syndrome [PCOS],” researchers found after assigning “four women with PCOS and obesity and four control participants with obesity but not PCOS to a single 40-minute bout of aerobic exercise after an overnight fast,” then taking muscle samples. The findings were published online in Clinical Endocrinology. Exercise has been considered the first-choice treatment to offset insulin resistance by enhancing the insulin-mediated molecular pathway and stimulating GLUT4 translocation via insulin-dependent pathways. In PCOS, however, exercise training was unable to resolve insulin resistance.” Researchers identified a “significant upregulation” of six different genes in the PCOS group, including NFKBIA, MAPK3, PPARGC1A and PPARA. In the control group, the researchers reported, 12 genes were upregulated after exercise: LEPR, CXCR4, CCR5, IL18R1, CRLF2, ACACA, CEBPA, PPARGC1A, UCP1, TNFSRF1B, TLR4 and IKBKB. The PCOS group showed upregulation of three genes after exercise: SOCS3, NAMPT and IL8. The IL-6 gene was upregulated in both groups after the exercise session, http://www.healio.com/endocrinology/reproduction-androgen-disorders/news/in-the-journals/%7Bd7753e5f-69da-4671-8948-a4a8e62188e8%7D/exercise-alters-expression-of-insulin-related-genes-in-women-with-pcos