Do Obesity and Depression Have Immunometabolic Ties? Disorders may share pathophysiologic mechanisms

The shared pathophysiologic mechanisms may include immunometabolic pathways characterized by an increased pro-inflammatory response and the dysregulation of hormones responsible for energy metabolism. "Obesity is characterized by low-grade pro-inflammatory activation. Peripheral immune activation could trigger brain inflammatory responses participating in depressive neurochemical and/or endocrine processes (i.e., depletion and degradation of tryptophan toward neurotoxic end products or hyperactivation of the hypothalamic-pituitary-adrenal axis)," they wrote. https://www.medpagetoday.com/endocrinology/obesity/68627