Scientists Reverse Tau Pathology With Drug

Reversing memory deficits and impairments in spatial learning is a major goal in the field of dementia research. A lack of knowledge about cellular pathways critical to the development of dementia, however, has stood in the way of significant clinical advance. But now, researchers at the Lewis Katz School of Medicine at Temple University (LKSOM) are breaking through that barrier. They show, for the first time in an animal model, that tau pathology – the second-most important lesion in the brain in patients with Alzheimer's disease – can be reversed by a drug. “We show that we can intervene after disease is established and pharmacologically rescue mice that have tau-induced memory deficits,” explained senior investigator Domenico Praticò, MD, Scott Richards North Star Foundation Chair for Alzheimer’s Research, Professor in the Departments of Pharmacology and Microbiology, and Director of the Alzheimer’s Center at Temple at LKSOM. The study, published online in the journal Molecular Neurobiology, raises new hope for human patients affected by dementia. https://www.technologynetworks.com/neuroscience/news/scientists-reverse-tau-pathology-with-drug-304919?utm_campaign=Newsletter_TN_BreakingScienceNews&utm_source=hs_email&utm_medium=email&utm_content=63648751&_hsenc=p2ANqtz-9mj6Eu4Wou1uucfRBK1qmZ4wegcu-UERbphjba5m5MvkILUr8IHU8aR9e96l0WWXMaVurHUXcxYK066rL5-DiMRn_aFA&_hsmi=63648751