Fecal Transplant to Treat Obesity and Diabetes?

The study's primary outcomes were the procedure's safety and its effects on glucagon-like peptide-1 (GLP-1), which is associated with the satiety reflex and associated with weight gain and loss. While the procedure appeared relatively safe (no adverse events worse than grade 1), no increase in the area under the curve for GLP-1 in either group at 12 weeks compared to baseline. And no change in mean body weight was seen. But participants' microbiota did change with FMT, with the microbial makeup of their stools becoming more similar to that of the donor. Allegretti and colleagues also noticed alterations in patients' bile acid profiles.So much of digestion occurs in the small intestine, and what we are giving these patients is essentially the bacteria that is in the large intestine," Zarrinpar said. "Can we better select what is being transplanted?" https://www.medpagetoday.com/meetingcoverage/ddw/79957