Endocannabinoid Signaling Drives Overeating in the Mouse Brain

The researchers detected high activity of endocannabinoids at cannabinoid CB1 receptors in the gut of mice that were fed a high-fat and sugar -- or Western -- diet for 60 days. This overactivity, they found, prevented the food-induced secretion of the satiation peptide cholecystokinin, a short chain of amino acids whose function is to inhibit eating. This resulted in the mice overeating. Cannabinoid CB1 receptors and cholecystokinin are present in all mammals, including humans. https://www.technologynetworks.com/neuroscience/news/endocannabinoid-signaling-drives-overeating-in-the-mouse-brain-320531?utm_campaign=NEWSLETTER_TN_Breaking%20Science%20News&utm_source=hs_email&utm_medium=email&utm_content=73600339&_hsenc=p2ANqtz--_2sPcLdSajLSfBQeK0NfMaKga0zSzUAH_cqoFLYLxF1cXlXy1OWvNAiVeB8Hp8Bn7bzkNPtcoC1jXPuMv6Ge3hQNbpA&_hsmi=73600339