Study: Combination Of Orlistat And Acarbose May Facilitate Weight Loss With Fewer GI Effects Vs. Orlistat Alone

“modified-release fixed-dose formulation of orlistat and acarbose is well tolerated and may be an effective approach for weight loss, according to results of a phase 2a pilot study published in Obesity Science and Practice.” Researchers “conducted a single-center, randomized, controlled, parallel-group, study to compare the effects on appetite and tolerability of orlistat (Xenical, Roche) vs. three doses of a modified-release fixed-dose formulation of orlistat plus acarbose.” According to the researchers, the combination “is designed to provide the weight-loss effects of orlistat and to reduce orlistat’s tendency to stimulate appetite with acarbose,” and they “cautioned that prescribing orlistat together with conventional acarbose is not recommended.” https://www.healio.com/endocrinology/obesity/news/online/%7Bc788df4a-14a2-4799-b088-ea5cc2b9b661%7D/orlistat-acarbose-combination-may-facilitate-weight-loss-with-fewer-gi-effects-vs-orlistat-alone