Dr. House
Dr. House
Thursday, May 7, 2020
Brain-like Tissue Model Links Alzheimer's to Herpes Virus
Engineers and scientists led by Tufts University used a three-dimensional (3D) human tissue culture model mimicking the components and conditions in the brain to demonstrate a possible causal relationship between sporadic Alzheimer’s disease and herpes simplex virus I infection (HSV-1). Reported in Science Advances, the model will allow for further studies into the causes and possible treatments of this devastating neurodegenerative condition.
After infecting neurons in the bioengineered brain model with HSV-1, the researchers observed formation of amyloid plaques, neuronal loss, neuroinflammation and diminished neural network functionality, all typical features of Alzheimer’s disease. Treatment of the brain tissue models with the antiviral drug valacyclovir resulted in reduced plaque formation and other markers of the disease.
Studies by other researchers have implicated pathogens as environmental agents possibly causing the development of Alzheimer’s disease, with a number of studies pointing to HSV-1.
“Our brain tissue model allowed us to take a closer look at the potential causal relationship between herpes and Alzheimer’s disease, and the results were intriguing,” said David Kaplan, Stern Family Professor of Engineering and chair of the Department of Biomedical Engineering at Tufts’ School of Engineering. “After just 3 days of herpes infection, we saw large and dense plaque formations of beta amyloid protein, as well as increased expression of some of the enzymes responsible for generating the plaques. We observed neuron loss, neuroinflammation and depressed signaling between neurons – everything we observe in patients. Never before have so many facets of the disease been replicated in vitro.”
https://www.technologynetworks.com/neuroscience/news/brain-like-tissue-model-links-alzheimers-to-herpes-virus-334518?utm_campaign=NEWSLETTER_TN_Breaking%20Science%20News&utm_source=hs_email&utm_medium=email&utm_content=87564397&_hsenc=p2ANqtz-95VWtXx2fdZF9lQCu03eJd3CAHEq9cSonVIDkfzS4q94au3uIQCkx-LN48ONAENAPnQ6uqpD_qPGBeb9dmGYVT4f2MdQ&_hsmi=87564397
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Very Interesting. A beginners question here, Is it possible that plaque formations of beta amyloid protein are meant to cocoon the brain as a form of protection from viruses?
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