Dr. House

Dr. House
Dr. House

Thursday, October 31, 2019

Immune Response Against Skin-dwelling Viruses Stops Cancer

Viruses get a bad rap as potential cancer-causers, but at least one class of viruses that commonly live on human skin - so-called "low-risk" human papillomaviruses - appear to play an unwitting role in protecting us against skin cancer according to a new study published in Nature. Patients who have immune systems that are suppressed from diseases or medical therapy are at greatly increased risk for cancers linked to viral infections, particularly squamous cell carcinoma (SCC) of the skin. Although multiple studies have tried to show a link between human papillomavirus (HPV) infections and SCC, none have been able to show that HPVs actually drive the development of these common skin cancers, say Shawn Demehri, MD, PhD investigator in the Center for Cancer Immunology at Massachusetts General Hospital (MGH) department of Dermatology and the MGH Cancer Center, and colleagues. Instead, working with experimental models and tissue samples from human skin cancer, they found that the presence of "commensal" papillomaviruses - low-risk forms of HPV that dwell on the skin of a large majority of people - appears to have an indirect protective rather than harmful effects against SCC. "This is the first evidence that commensal viruses could have beneficial health effects both in experimental models and also in humans, and it turns out that this beneficial effect has to do with cancer protection. The role of these commensal viruses, in this case papillomaviruses, is to induce immunity that then is protecting patients from skin cancers," he says. https://www.technologynetworks.com/cancer-research/news/immune-response-against-skin-dwelling-viruses-stops-cancer-326626?utm_campaign=NEWSLETTER_TN_Breaking%20Science%20News&utm_source=hs_email&utm_medium=email&utm_content=78793302&_hsenc=p2ANqtz-9FyKGcjw68GgKrX9Kkb1qNHTItm60pPw9PPOkjLw2hsqYMp-LqWQlrQlx6TBvlk03jhArzOBT3bQZaboOrpq1FOfJtKA&_hsmi=78793302

Bariatric Surgery May Reduce Skin Cancer Risk In People With Obesity

reports researchers found “bariatric surgery cut skin cancer risk in people with obesity.” The findings were published in JAMA Dermatology. https://www.medpagetoday.com/dermatology/skincancer/83042

Reresearch Indicates Teens Who Take Oral Contraceptives More Likely To Experience Depressive Symptoms

reports a study of 1,010 girls and women over nine years showed “teenage girls who use birth control pills are more likely to cry, sleep too much and experience eating issues than their peers who don’t use oral contraceptives.” While “research has shown that adolescents who use birth control pills are more prone to be at risk for depression in adulthood,” the investigators “sought to examine something more subtle – depressive symptoms, which include increased crying, sleeping too much, feelings of worthlessness and suicidal thoughts.” The study was published in JAMA Psychiatry. https://www.cnn.com/2019/10/30/health/teens-birth-control-pills-depressive-symptoms-trnd/index.html

Wednesday, October 30, 2019

Patients With T2D May Be More Likely To Carry Candida Albicans In Their Root Canals, Study Indicates

reports researchers found that “patients with a long-term history of [T2D] carried Candida albicans in their dental root canals more frequently when they have a primary endodontic infection.” The findings were published in the European Journal of Clinical Microbiology & Infectious Diseases. https://www.infectiousdiseaseadvisor.com/home/topics/mycoses/people-with-diabetes-more-commonly-have-candida-fungus-present-in-teeth-root-canals/

FDA Releases Report On Drug Shortages

An analysis in the report found that two-thirds of 163 drugs in short supply in recent years were available as generics, generally at low cost.” The drugs “were older, too, on the market for a median of almost 35 years.” However, “quality-control problems at manufacturing facilities were responsible for more than half of recent drug shortages, the task force also found.” https://www.nytimes.com/2019/10/29/health/drug-shortages-generics.html

Tuesday, October 29, 2019

Salt May Be Involved In Weight Gain,

https://consumer.healthday.com/vitamins-and-nutrition-information-27/salt-and-sodium-news-591/too-much-salt-might-make-you-gain-weight-750780.html

Healthcare Workers Among The “Hardest Hit” By Sleep Deprivation, Study Suggests

“The number of working Americans who get less than seven hours of sleep a night is on the rise. And the people hardest hit when it comes to sleep deprivation are those we depend on the most for our health and safety: police and health care workers.” A recent study published in the Journal of Community Health “found the prevalence of inadequate sleep, defined as seven hours or less, increased from 30.9% in 2010 to 35.6% in 2018.” Meanwhile, 45 percent of healthcare workers “reported not getting seven hours a night. For many, the norm was six or even just five hours.” https://www.npr.org/sections/health-shots/2019/10/28/773622789/working-americans-are-getting-less-sleep-especially-those-who-save-our-lives

Friday, October 25, 2019

Sunlight Exposure Is Reflected in Your Poop

the Sun can indeed shine out of your backside, suggests research. Not because you’re self-absorbed, but because you’ve absorbed gut-altering UV radiation. This is the first study to show that skin exposure to UVB light alters the gut microbiome in humans. Published in Frontiers in Microbiology, the analysis suggests that vitamin D mediates the change – which could help explain the protective effect of UVB light in inflammatory diseases like MS and IBD. Ratifying rodent studies Sun exposure, vitamin D levels and the mix of bacteria in our gut are each associated with risk of inflammatory conditions like MS and IBD. Scientists hypothesize that a causal chain links the three. Exposure to UVB in sunlight is well-known to drive vitamin D production in the skin, and recent studies suggest that vitamin D alters the human gut microbiome. However, that UVB therefore causes gut microbiome changes, via vitamin D production, has so far been shown only in rodents. https://www.technologynetworks.com/tn/news/sunlight-exposure-is-reflected-in-your-poop-326420?utm_campaign=NEWSLETTER_TN_Breaking%20Science%20News&utm_source=hs_email&utm_medium=email&utm_content=78538930&_hsenc=p2ANqtz-9xKZWZkOcvC61rINGuGspIVR4Q_pCP-hyBf_KZezZx66RDOOA-_a14ZOZyj3YgBeLaAXPyNwbAUfdpQdTAm8tBW8Q2vQ&_hsmi=78538930

Wednesday, October 23, 2019

Blood Pressure Drugs Work Best at Bedtime

People with high blood pressure who take all their anti-hypertensive medication in one go at bedtime have better controlled blood pressure and a significantly lower risk of death or illness caused by heart or blood vessel problems, compared to those who take their medication in the morning, according to new research. https://www.technologynetworks.com/drug-discovery/news/blood-pressure-drugs-work-best-at-bedtime-326322?utm_campaign=NEWSLETTER_TN_Breaking%20Science%20News&utm_source=hs_email&utm_medium=email&utm_content=78422920&_hsenc=p2ANqtz-_FGVHgZ11ieJlQs5fIcuPzrO6TcQKG7MOBlsDH2SjFMrxOtrnPaj09XiZHY0GrJOTn-JlU7T919EjwG_mgEhASDQ-0qQ&_hsmi=78422920

Monday, October 21, 2019

Review Study Suggests Intermittent Fasting Diet May Be Beneficial For Reducing BMI And Improving Glycemic Control

An intermittent fasting diet may be beneficial for reducing body mass index (BMI) and improving glycemic control,” researchers concluded in a 12-study “systematic review and meta-analysis.” The findings were published online in the Journal of Clinical Medicine. https://www.endocrinologyadvisor.com/home/topics/general-endocrinology/review-investigates-effects-of-intermittent-fasting/

Creatine Fuels T Cells’ Fight Against Cancer

Creatine, the organic acid that is popularly taken as a supplement by athletes and bodybuilders, serves as a molecular battery for immune cells by storing and distributing energy to power their fight against cancer, according to new UCLA research. The study, conducted in mice and published in the Journal of Experimental Medicine, is the first to show that creatine uptake is critical to the anti-tumor activities of CD8 T cells, also known as killer T cells, the foot soldiers of the immune system. The researchers also found that creatine supplementation can improve the efficacy of existing immunotherapies. “Because oral creatine supplements have been broadly utilized by bodybuilders and athletes for the past three decades, existing data suggest they are likely safe when taken at appropriate doses,” said Lili Yang, a member of the Eli and Edythe Broad Center of Regenerative Medicine and Stem Cell Research at UCLA and the study’s senior author. “This could provide a clear and expedient path forward for the use of creatine supplementation to enhance existing cancer immunotherapies.” https://www.technologynetworks.com/cancer-research/news/creatine-fuels-t-cells-fight-against-cancer-326197?utm_campaign=NEWSLETTER_TN_Breaking%20Science%20News&utm_source=hs_email&utm_medium=email&utm_content=78310030&_hsenc=p2ANqtz-9ROP3PYOUFRqcnAAr0Ao8sz7LvNNVmshJSiPmtNzYtqgeqnQnzqJ6P-YzgpyFniC5l4EbKHCPv5u_3Y_PDL98VUkEZuQ&_hsmi=78310030

Thursday, October 17, 2019

Time To Say Goodbye… to the “Household Measure” BMI?

https://www.technologynetworks.com/proteomics/news/time-to-say-goodbye-to-the-house-hold-measure-bmi-325276?utm_campaign=NEWSLETTER_TN_Breaking%20Science%20News&utm_source=hs_email&utm_medium=email&utm_content=78194095&_hsenc=p2ANqtz-9FqcLND-o7pOJywQkKWmH5kx4lgk50OhOoyJ-6Z5JeDQbt9tSl9AWjCC6OMagxa_Gul-8jh6vn3lZ1uNuPIUKh8kZt4w&_hsmi=78194095

Even Short-term Vaping Causes Inflammation in Non-smokers

https://www.technologynetworks.com/cancer-research/news/even-short-term-vaping-causes-inflammation-in-non-smokers-says-pilot-study-325362?utm_campaign=NEWSLETTER_TN_Breaking%20Science%20News&utm_source=hs_email&utm_medium=email&utm_content=78194095&_hsenc=p2ANqtz-9FqcLND-o7pOJywQkKWmH5kx4lgk50OhOoyJ-6Z5JeDQbt9tSl9AWjCC6OMagxa_Gul-8jh6vn3lZ1uNuPIUKh8kZt4w&_hsmi=78194095

Research Suggests Association Between Irregular Menstrual Cycle And Mortality Risk

reports a “study found that women who had irregular periods or extra-long menstrual cycles had as much as a one-third higher risk of death during the two-decade study compared to women who usually had a normal menstrual cycle.” In the study of almost 94,000 women “women who had longer-than-average menstrual cycles (more than 32 days) were around 25% more likely to die from any cause during the study than women with a usual cycle length of 26 to 31 days.” The results only show an association, which “may have something to do with other risk factors that boost the odds of dying early.” The findings were scheduled to be presented at the American Society for Reproductive Medicine meeting. https://consumer.healthday.com/pregnancy-information-29/menstruation-news-473/irregular-periods-shorter-life-span-751275.html

Friday, October 11, 2019

Viagra – The Little Blue Pill Could Reshape Bone Marrow Transplants

https://www.technologynetworks.com/biopharma/news/viagra-the-little-blue-pill-could-reshape-bone-marrow-transplants-324976?utm_campaign=NEWSLETTER_TN_Breaking%20Science%20News&utm_source=hs_email&utm_medium=email&utm_content=77954506&_hsenc=p2ANqtz-9pZ5xEXFwja4QNXh3jlbckIn3DKNHJsg9ypPnFUFZafawroqXDsw9IFejg9xP4giWco_YHR2mspLTm-qZ0B1BP6rVlVw&_hsmi=77954506

Harmful Bacteria Combated by Breast Milk Compound

Researchers at National Jewish Health and the University of Iowa have identified a compound in human breast milk that fights infections by harmful bacteria while allowing beneficial bacteria to thrive. Human breast milk has more than 200 times the amount of glycerol monolaurate (GML) than is found in cows’ milk. Infant formula has none. GML is inexpensive to manufacture. Future research will determine if GML could be a beneficial additive to cow’s milk and infant formula. “Our findings demonstrate that high levels of GML are unique to human breast milk and strongly inhibit growth of pathogenic bacteria,” said Donald Leung, MD, PhD, professor of pediatrics at National Jewish Health and senior author on a paper in Scientific Reports. ‘While antibiotics can fight bacterial infections in infants, they kill the beneficial bacteria along with the pathogenic ones,” said Patrick Schlievert, PhD, professor of microbiology and immunology at the University of Iowa Carver College of Medicine and first author on the Scientific Reports paper. “GML is much more selective, fighting only the pathogenic bacteria while allowing beneficial species to thrive. We think GML holds great promise as a potential additive to cows’ milk and infant formula that could promote the health of babies around the world.” https://www.technologynetworks.com/applied-sciences/news/harmful-bacteria-combated-by-breast-milk-compound-325053?utm_campaign=NEWSLETTER_TN_Breaking%20Science%20News&utm_source=hs_email&utm_medium=email&utm_content=77954506&_hsenc=p2ANqtz-9pZ5xEXFwja4QNXh3jlbckIn3DKNHJsg9ypPnFUFZafawroqXDsw9IFejg9xP4giWco_YHR2mspLTm-qZ0B1BP6rVlVw&_hsmi=77954506

Thursday, October 10, 2019

Review Suggests Medical Schools Don’t Spend Much Time On Nutrition

reports a new research review suggests that “although diet plays an outsize role in health and wellness and can be crucial to managing many common chronic conditions, medical schools tend not to devote much time to teaching future doctors about nutrition.” Researchers “analyzed data from 24 previously published studies that focused on medical students’ nutrition knowledge and confidence in their ability to counsel patients on diet.” Their findings and an accompanying editorial were published in The Lancet Planetary Health. https://www.reuters.com/article/us-health-nutrition-medical-education/medical-education-not-covering-basics-of-nutrition-idUSKBN1WO2S3

Drug Abstinence Changes Gene Expression, Making Relapse More Likely

prolonged abstinence “The novelty of our current paper is that it begins to reveal what happens on a cellular basis, what genes are turned on and off during a prolonged period of abstinence,” said David M. Dietz, PhD, senior author and chair of the Department of Pharmacology and Toxicology. The research focused on the nucleus accumbens, a center of reward and motivation in the brain. The researchers looked specifically at molecules known as chromatin remodelers that can facilitate or prevent access to DNA, ultimately affecting gene expression. They found that chromatin remodeler INO80 causes changes in gene expression that enhances cocaine-craving behavior. While after one day of abstinence from cocaine there was no change in expression of INO80, there was a significant increase after 30 days of abstinence. The findings also reveal how a class of proteins called E3 ubiquitin ligases facilitates relapse. Currently the subject of well-funded research in the pharmaceutical industry for psychiatric and neurologic diseases, E3 ubiquitin ligase proteins have yet to be well-explored in terms of their relevance to addiction and relapse. Last year, Werner and his colleagues at UB published the first paper regarding another one of these proteins and its role in addiction and relapse. The current UB study reveals that an E3 ubiquitin ligase called TRIM3 tags INO80 with a ubiquitin chain indicating to the cell to degrade INO80. The researchers found that a decrease in TRIM3 likely underlies the observed increase in INO80 (less TRIM3 means less INO80 being degraded). Increased drug craving “When there’s less TRIM3 and more INO80, that leads to an increase in drug craving,” said Werner, “but when there’s more TRIM3 and less INO80, drug-craving behavior is reduced.” They found this effect whether they manipulated INO80 directly, or through the alterations of TRIM3 levels, he said. “INO80 affects some combination of target genes,” said Werner. “In the future, we want to find out which of those downstream genes are contributing to drug-craving behaviors. This would be a big first step into this really new territory of how gene expression maintains relapse https://www.technologynetworks.com/genomics/news/drug-abstinence-changes-gene-expression-making-relapse-more-likely-325007?utm_campaign=NEWSLETTER_TN_Breaking%20Science%20News&utm_source=hs_email&utm_medium=email&utm_content=77906125&_hsenc=p2ANqtz-_45dRrGuKf0380b4bbq5aK1MhmjqD0QXrjFYGaN2sAX32wtw4I2YLiX29AuE8kyRpECmoz8HWvFGdxR9WEt0PzMrJm-A&_hsmi=77906125

Brain Tissue Kept Alive for a Month on Microfluidic Device

https://www.technologynetworks.com/neuroscience/news/brain-tissue-kept-alive-for-a-month-on-microfluidic-device-325005?utm_campaign=NEWSLETTER_TN_Breaking%20Science%20News&utm_source=hs_email&utm_medium=email&utm_content=77906125&_hsenc=p2ANqtz-_45dRrGuKf0380b4bbq5aK1MhmjqD0QXrjFYGaN2sAX32wtw4I2YLiX29AuE8kyRpECmoz8HWvFGdxR9WEt0PzMrJm-A&_hsmi=77906125

Wednesday, October 9, 2019

Probiotic Supplements May Improve BMI, Inflammatory Markers, Glycolipid Metabolism In Obese Children Following Diet And Exercise Plan, Research Suggests

Probiotic supplements can improve body mass index (BMI), inflammatory markers, and glycolipid metabolism in obese children who are following a diet and exercise plan,” research indicated. The findings of the 54-patient study were presented in a poster at the 58th Annual European Society for Paediatric Endocrinology Meeting. https://www.endocrinologyadvisor.com/home/topics/pediatric-endocrinology/probiotics-may-improve-body-mass-index-in-obese-children/

Parental Pressure On Teens To Diet Or Lose Weight May Boost Teens’ Odds For Obesity Later In Life, Study Indicates

reports that parental pressure on teens “to diet or lose weight may end up harming them,” researchers concluded after examining “data from surveys completed by more than 1,100 adolescents from the Minneapolis-St. Paul area from 1998 to 1999,” then having respondents “fill out follow-up surveys at five-year intervals beginning in 2003, until they entered their 30s.” The study revealed that “parents who urge their kids to diet might actually be boosting their odds for obesity later in life.” The findings were published online in the Journal of Adolescent Health. https://consumer.healthday.com/kids-health-information-23/adolescents-and-teen-health-news-719/pressuring-kids-to-diet-can-backfire-damaging-long-term-health-751019.html

CDC Says Reported Cases Of STDs Have Reached Record Highs

The number of combined cases of syphilis, gonorrhea and chlamydia in the United States rose to a record high last year...according to figures released by the Centers for Disease Control and Prevention.” Reuters (10/8, Borter) reports that the agency said that last year, there were nearly 2.46 million reported cases of STDs in the US. https://www.nytimes.com/2019/10/08/health/cdc-std-study.html

Tuesday, October 8, 2019

US Measles Cases Rise To 1,250 This Year

reports seven new measles cases were recorded in the United States last week, “taking the total cases for the year to 1,250” in “the worst outbreak since 1992.” The CDC said that, as of Oct. 3, measles has been reported in 31 states. https://www.reuters.com/article/us-usa-measles/u-s-recorded-seven-new-cases-of-measles-last-week-idUSKBN1WM1HO

Harmful Air Pollutants Generated by Some Bleach Products

https://www.technologynetworks.com/applied-sciences/news/harmful-air-pollutants-generated-by-some-bleach-products-324871?utm_campaign=NEWSLETTER_TN_Breaking%20Science%20News&utm_source=hs_email&utm_medium=email&utm_content=77790934&_hsenc=p2ANqtz-8xOpWCPUXxQY9dMGt61CqAl1dbBJZECHenWbjQriLWPhbclSaYNFyZABJp7KxutisjXcgJZYQE1PxYv-j8PUuK2Fa6fA&_hsmi=77790934 Bleach cleaning products emit chlorine-containing compounds, such as hypochlorous acid (HOCl) and chlorine gas (Cl2), that can accumulate to relatively high levels in poorly ventilated indoor environments. These gases can react with other chemicals commonly found in homes, such as limonene –– an orange- or lemon-scented compound added to many personal care products, cleaners and air fresheners. In addition, indoor lighting or sunshine through windows might split HOCl and Cl2 into a hydroxyl radical and a chlorine atom, which can react with other compounds to form air particles called secondary organic aerosols (SOAs). These pollutants have been linked to respiratory problems and other adverse health effects. Chen Wang and colleagues wanted to see whether limonene and bleach fumes, at concentrations likely to occur in indoor environments, could react to produce SOAs under light and dark conditions.

Saturday, October 5, 2019

Serum Interferon Predicts Lupus Flares High levels of interferon-alpha linked with fourfold greater risk of flare within a year

The persistent presence of interferon-α may not merely be a marker of disease activity during apparent remission, but also may play a pathologic role in the disease. "Interferon-α overexpression could be an explanation of chronic fatigue, depression, and reduction of sleep secondary to the stimulation of the dopamine metabolism by interferon-α in the central neurological system," the authors suggested. Interferon-α also may participate in some of the processes linked with the accelerated atherosclerosis seen in SLE, such as endothelial cell damage. "These data suggest that for patients in clinical remission, return of serum interferon-α to normal values could become one of the objectives of https://www.medpagetoday.com/rheumatology/lupus/82577?xid=nl_mpt_DHE_2019-10-05&eun=g721819d0r&utm_source=Sailthru&utm_medium=email&utm_campaign=Daily%20Headlines%202019-10-05&utm_term=NL_Daily_DHE_Active

Wednesday, October 2, 2019

Research Suggests Maintaining Weight Loss Requires More Than Willpower

reports a brain imaging study published in Cognitive Neuroscience indicates “some people have an imbalance between the executive control and reward systems of the brain,” which suggests they “not have enough natural control over the impulse to reach for food.” A separate study published in Obesity “found that the body’s internal protection against starvation encourages eating specifically so that you’ll regain any lost weight – and at a rate of 100 calories a day for every kilogram or 2.2 pounds dropped.” A third study published in the American Journal of Preventive Medicine suggests techniques that work for weight loss are ineffective for weight loss maintenance, such as meal planning and participating in many different types of exercise. https://consumer.healthday.com/vitamins-and-nutrition-information-27/dieting-to-gain-or-maintain-weight-192/why-maintaining-weight-loss-demands-more-than-willpower-750112.html

Inflammatory Protein Could Put the Brakes on Alzheimer's

https://www.technologynetworks.com/neuroscience/news/inflammatory-protein-could-put-the-brakes-on-alzheimers-324594?utm_campaign=NEWSLETTER_TN_Breaking%20Science%20News&utm_source=hs_email&utm_medium=email&utm_content=77561277&_hsenc=p2ANqtz-8nRlxl8_8H61IBZVLL14sxwoGTInyHMH4yf17wbH2UxJQAbjci_pb5KHYOfCBEURx4CTxyCXQoxYRTvYm6avGjloCPLw&_hsmi=77561277

Tuesday, October 1, 2019

Exposure To Air Pollution Tied To Increased Risk For Death Among Babies And Reduced Lung Function In Childhood,

“Exposure to air pollution is associated with an increased risk for death among babies and reduced lung function in childhood,” researchers concluded in “two studies presented at the European Respiratory Society International Congress.” https://www.healio.com/pulmonology/practice-management/news/online/%7Bb8f3500b-49c2-45e9-ac4e-4121e977fb73%7D/air-pollution-may-pose-significant-risks-to-newborns-children

Bones Of Healthy Adults May Not Benefit From High-Dose, Daily Vitamin D, Study Indicates

“Supplementation with high-dose, daily vitamin D does not prevent bone loss or benefit bone structure over two years, or reduce the risk of falls over five years versus placebo...two subanalyses of a large nationwide study of healthy men and women without vitamin D insufficiency at baseline” indicated. The findings of the “largest randomized controlled trial in healthy women and men of supplemental vitamin D3 alone versus placebo on spine and hip areal bone mineral density...and measures of bone structure” were presented at the American Society for Bone and Mineral Research 2019 Annual Meeting. https://www.medscape.com/viewarticle/919179

Culprit for Age-related Decline in Muscle Healing Uncovered

An age-related decline in recovery from muscle injury can be traced to a protein that suppresses the special ability of muscle stem cells to build new muscles, according to work from a team of current and former Carnegie biologists led by Chen-Ming Fan and published in Nature Metabolism. Skeletal muscles have a tremendous capacity to make new muscles from special muscle stem cells. These "blank" cells are not only good at making muscles but also at generating more of themselves, a process called self-renewal. But their amazing abilities diminish with age, resulting in poorer muscle regeneration from muscle trauma. The research team--including Carnegie's Liangji Li, Michelle Rozo, Sibiao Yue, Xiaobin Zheng, and Frederick Tan, as well as Christoph Lepper formerly of Carnegie now at the Ohio State University--figured out that a protein called GAS1 is the culprit for this age-related decline. "Encoded by the growth-arrest specific gene, the GAS1 protein lives up to its name, accelerating the functional decline of muscle stem cells," explained lead author Li. The protein is found in only a small number of young muscle stem cells, but is present in all aged muscle stem cells, they discovered. Tinkering with muscle stem cells to express GAS1 in the https://www.technologynetworks.com/drug-discovery/news/culprit-for-age-related-decline-in-muscle-healing-uncovered-324512?utm_campaign=NEWSLETTER_TN_Breaking%20Science%20News&utm_source=hs_email&utm_medium=email&utm_content=77506203&_hsenc=p2ANqtz--rjolzNTyeSIZQO2DzyIpYOqAzldhTtZVEgxSj93ElClROuOL0LoQwrtfOi0bgPDFG12U088ztoP6mPDo04WdjeQDJrQ&_hsmi=77506203