Dr. House
Dr. House
Friday, May 4, 2018
Fasting Boosts Stem Cells’ Regenerative Capacity
https://www.technologynetworks.com/cell-science/news/fasting-boosts-stem-cells-regenerative-capacity-300462?utm_campaign=Newsletter_TN_BreakingScienceNews&utm_source=hs_email&utm_medium=email&utm_content=62676901&_hsenc=p2ANqtz-_oKevs-x8VvIHT0Vb2Dl-eXpfYjmTgSudr3WYNR9ZOl38f1BUpAC_t3CQjUnPbtz2_dLEjkDGEhH1ZFo1OoHMQgSOFtw&_hsmi=62676901
This study provided evidence that fasting induces a metabolic switch in the intestinal stem cells, from utilizing carbohydrates to burning fat,” Sabatini says. “Interestingly, switching these cells to fatty acid oxidation enhanced their function significantly. Pharmacological targeting of this pathway may provide a therapeutic opportunity to improve tissue homeostasis in age-associated pathologies.”
Thursday, May 3, 2018
Targeting Gut Bacteria to Reduce Disease
merging evidence suggests that microbes in the digestive system have a big influence on human health and may play a role in the onset of disease throughout the body. Now, in a study appearing in ACS Chemical Biology, scientists report that they have potentially found a way to use chemical compounds to target and inhibit the growth of specific microbes in the gut associated with diseases without causing harm to other beneficial organisms.
The digestive system is crammed with trillions of bacteria, fungi, and other microbes that help process food. Recent studies suggest that the changes in these gut flora, or microbiome, may play a role in the onset of a host of diseases and conditions including obesity, diabetes, cancer, allergies, asthma, autism and multiple sclerosis. Antibiotics can help regulate the microbiome, but bacterial resistance is on the rise. In addition, antibiotics can wipe out some of the organisms that contribute to a healthy microbiome, and the microbes that take their place can sometimes cause more harm than good. Researchers have also investigated using probiotics and fecal transplants to resolve some of these problems. But to date, few have really looked at using non-microbicidal small molecules to alter the microbiome in a targeted way to improve health. To help fill this gap, Daniel Whitehead, Kristi Whitehead and colleagues sought to use a chemical compound to precisely target and disrupt the metabolic processes of members of the Bacteroides genus, a group of bacteria commonly found in the gut that appear to be associated with the onset of type I diabetes in genetically susceptible individuals.https://www.technologynetworks.com/tn/news/targeting-gut-bacteria-to-reduce-disease-300423?utm_campaign=Newsletter_TN_BreakingScienceNews&utm_source=hs_email&utm_medium=email&utm_content=62644895&_hsenc=p2ANqtz-_0O1pU78ryox1kASHkQX6lSuayE6FwF3I5WZ2HMWNwlKnvSfOxjIFL26HiZDsUyvRxhd7mRHh8fElvCmML9UI1WuC4gw&_hsmi=62644895
Wednesday, May 2, 2018
Significant Link Between Common Allergic Diseases and Psychiatric Disorders
Patients with asthma and hay fever have an increased risk of developing psychiatric disorders, finds a new study published in Frontiers in Psychiatry. Almost 11% of patients with common allergic diseases developed a psychiatric disorder within a 15-year period, compared to only 6.7% of those without — a 1.66-fold increased risk. While previous studies have linked allergies with certain psychiatric or emotional disorders, this is the first to find a connection between common allergies and the overall risk of developing psychiatric disorders. The findings could have implications for how doctors care for and monitor patients with allergic diseases.
Asthma, allergic rhinitis (hay fever) and atopic dermatitis (eczema), are among some of the most common allergic diseases and are nicknamed the three “A”s. Dr. Nian-Sheng Tzeng, from Tri-Service General Hospital in Taiwan and lead author of the study, noticed something unexpected about these patients.
“As a clinician, I observed that some patients with the three ‘A’s appeared to suffer emotionally,” says Tzeng. “Therefore, I wanted to clarify whether these allergic diseases are associated with psychiatric disorders.” https://www.technologynetworks.com/tn/news/significant-link-between-common-allergic-diseases-and-psychiatric-disorders-300347?utm_campaign=Newsletter_TN_BreakingScienceNews&utm_source=hs_email&utm_medium=email&utm_content=62610503&_hsenc=p2ANqtz-_QOziJoj_bxaESltsgywJBessmmMyklgw_KMvw8dMjGDJnn9wJK2BWp186IyEIUR5AUznkpVBcltmPAsZPqOJayEZWLw&_hsmi=62610503
Number Of Uninsured Americans Rose By Four Million In The Last Two Years, Analysis Indicates.
reports that some “4 million Americans lost health insurance in the last two years,” according to an analysis conducted by the Commonwealth Fund, “which attributed the decline to actions taken by the Trump administration.” Data show the uninsured rate rose “significantly compared with 2016 among adults with an individual income of about $30,000 and a family income of about $61,000.”
U.S. News & World Report (5/1, Williams) says the analysis concluded that “the erosion in coverage is likely due to Congress’ deciding not to shore up weaknesses in the” Affordable Care Act, “and to White House moves such as cutting advertising geared toward getting people to sign up for government-sponsored insurance plans.” The study also warned that this downward trend “is likely to continue in the foreseeable future,” partly because the tax reform bill repealed the ACA’s individual mandate. http://thehill.com/policy/healthcare/health-insurance/385680-poll-uninsured-rate-is-climbing
Giving Patients With T2D Access To Healthy Food At No Charge May Result In Improvements In Their Disease, Overall Quality Of Life.
“Giving patients with type 2 diabetes [T2D] access to healthy food at no charge can result in large improvements in their disease and overall quality of life,” researchers from the Geisinger Health System concluded. The findings were presented at the World Health Care Congress. https://www.medpagetoday.com/endocrinology/diabetes/72640
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