Dr. House
Dr. House
Friday, October 5, 2018
Blood Borne Viruses Target Gut Neurons
There are a number of people who are otherwise healthy who suddenly develop bowel motility problems, and we don’t understand why,” said Thaddeus S. Stappenbeck, MD, PhD, the Conan Professor of Laboratory and Genomic Medicine and the study’s co-senior author. “But now we believe that one explanation could be that you can get a viral infection that results in your immune cells killing infected neurons in your gut. That might be why all of a sudden you can’t move things along any more.”
Postdoctoral researcher and first author James White, PhD, was studying mice infected with West Nile virus, a mosquito-borne virus that causes inflammation in the brain, when he noticed something peculiar. The intestines of some of the infected mice were packed with waste higher up and empty farther down, as if they had a blockage https://www.technologynetworks.com/neuroscience/news/blood-borne-viruses-target-gut-neurons-310354?utm_campaign=Newsletter_TN_BreakingScienceNews&utm_source=hs_email&utm_medium=email&utm_content=66458113&_hsenc=p2ANqtz--0sw3LPvPtoAxmwJycc3KElE9z0qSmDIHQoMzkYl6e6dIb_mBfJt7wdCxF1vZeK7-dbqcCow_4kP6hryQ8cGWXLJD49Q&_hsmi=66458113
Thursday, October 4, 2018
Wednesday, October 3, 2018
Brain Network Localization of Free Will
Network mapping revealed that, while the brain injuries were quite diverse in their locations, the lesions fell within one of two distinct brain networks. All of the injuries disrupting volition were functionally connected to the anterior cingulate cortex, a region of the brain associated with motivation and planning. Ninety percent of lesions causing alien limb fell within a brain network functionally connected to the precuneus cortex, part of the brain associated with agency.
Finally, the authors showed that their findings were relevant beyond patients with brain injury. Brain stimulation to these same sites altered free will perception in healthy research participants, and neuroimaging of psychiatric patients with altered free will perception revealed abnormalities fell with these same brain networks.
“Our study was focused on patients with disorders of free will for movements; however, free will is commonly discussed as it relates to social, legal and moral responsibility for decisions, not just movement,” said Fox. “It remains unknown whether the network of brain regions we identify as related to free will for movements is the same as those important for moral decision-making. https://www.technologynetworks.com/neuroscience/news/brain-network-localization-of-free-will-310303?utm_campaign=Newsletter_TN_BreakingScienceNews&utm_source=hs_email&utm_medium=email&utm_content=66392011&_hsenc=p2ANqtz-9bmuBPbBULrx7zoYPtQVOoNDDGVtsPPjbtK9SXTbiRdDgBVK71KufqISgvsmkk_k_rLiTDWPSCtUiYJb833UYX5md3uQ&_hsmi=66392011
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