Marked Sex Difference Seen in Drug-Induced Liver Failure Brain damage, polypharmacy more common in women with ALF

Women with acetaminophen-induced acute liver failure are more likely than men to have severe hepatic encephalopathy, a researcher said here. That finding raises another question, Rubin said: why women would be more sensitive than men to the effects of co-ingestion of drugs. Future research, she added, should look at possible physiological and neurological explanations. The explanation behind the higher fragility of women when developing toxic hepatitis is currently unknown, but hormonal factors and the differences in body fat distribution could contribute," he added. http://www.medpagetoday.com/MeetingCoverage/AASLD/61385?xid=nl_mpt_DHE_2016-11-14&eun=g721819d0r&pos=4