to Search High-protein diet reverses prediabetes in adults with obesity

In a prospective, randomized trial, Stentz and colleagues analyzed data from 24 men and women with prediabetes (HbA1c, 5.7%-6.4%) and BMI between 30 kg/m² and 55 kg/m². Researchers randomly assigned 12 participants to a high-protein diet (30% kcal from protein; 40% kcal from carbohydrates; 30% kcal from fat) and 12 participants to a high-carbohydrate diet (15% kcal from protein; 55% kcal from carbohydrates; 30% kcal from fat). Participants underwent a mixed-meal tolerance and oral glucose tolerance testing at baseline and 6 months, as well as a DXA scan to assess body composition and indirect calorimetry to determine resting metabolic rate. Researchers established caloric needs for participants; 500 kcal were subtracted from the determined caloric needs to promote weight loss between 1 lb and 2 lb weekly. Participants came in weekly to pick up all food and daily food records; compliance and diet adherence was checked at pickup. At 6 months, all participants assigned to the high-protein diet experienced remission to normal glucose tolerance; 33% of participants in the high-carbohydrate group experienced remission. Both groups experienced weight loss at 6 months from baseline with no significant between-group differences. Both groups also experienced improvements in HbA1c and insulin sensitivity; however, improvements in the high-protein diet group were greater The high-protein group also saw greater improvements in triglycerides, LDL cholesterol, oxidative stress, tumor necrosis factor-alpha and interleukin-6, suggesting a better anti-inflammatory effect vs. the high-carbohydrate plan. “To the best of our knowledge, this is the first lifestyle intervention study where 100% remission of prediabetes was obtained,” the researchers wrote. http://www.healio.com/endocrinology/diabetes/news/in-the-journals/%7Bd927b791-f36e-4dc6-acdd-6a9409992c53%7D/high-protein-diet-reverses-prediabetes-in-adults-with-obesity