Sucralose May Adversely Affect Glucose Metabolism In Consumers With Obesity, Study Suggests.

reported, “Sucralose, a no-calorie sweetener widely used in beverages, may adversely affect glucose metabolism in consumers with obesity,” researchers found after conducting five-hour “modified oral glucose tolerance tests on two separate occasions in eight normal-weight adults (mean BMI, 22.9 kg/m²) and seven with obesity (mean BMI 37.9 kg/m²).” The findings were presented at Obesity http://www.healio.com/endocrinology/obesity/news/online/%7Bd976c2ee-06ee-425f-b1eb-aa3b6cbc2891%7D/non-nutritive-sweetener-effects-may-contribute-to-insulin-resistance-in-consumers-with-obesity There seem to be differential effects of sucralose on glucose metabolism in normal-weight people and in people with obesity, so previous findings in lean subjects cannot be extrapolated to what will be the effects of sucralose in subjects with obesity (and vice versa),” Marta Yanina Pepino De Gruev, PhD, assistant professor in food science and human nutrition at the University of Illinois in Urbana, told Endocrine Today. “Clinicians may find surprising that sucralose is not metabolically inert, as generally thought, at least for people with obesity.” Pepino reported that this finding replicated results from a previous trial conducted by her group “that acute sucralose consumption increases insulin responses to a glucose load in people with obesity, which in the long term may have adverse effects on glucose metabolism.” “Perhaps we should revise the recommendation of replacing sugar-sweetened beverages with non-caloric sweetened beverages for subjects with obesity who are trying to control their weight,” Pepino told Endocrine Today. “We may benefit from considering sweet-tasting beverages, regardless if sweetened with sugars or non-caloric sweeteners, really as a treat, and move toward the recommendation of replacing such beverages with water.”