Patients Taking A Fixed-Dose Combination Of Phentermine And Topiramate–ER Lost Over 15% Of Their Body Weight At 12 Months,

Patients who took a fixed-dose combination of phentermine and topiramate–extended release (ER) lost over 15% of their body weight at 12 months,” research indicated. The findings were presented at Obesity Week 2018. https://www.mdedge.com/endocrinology/article/191575/obesity/real-world-weight-loss-meds-approximates-rct-results Medical uses Topiramate is used to treat epilepsy in children and adults, and it was originally used as an anticonvulsant.[7] In children, it is indicated for the treatment of Lennox-Gastaut syndrome, a disorder that causes seizures and developmental delay. It is most frequently prescribed for, the prevention of migraines.[7] It decreases the frequency of attacks.[8][9] Pain A 2018 review found topiramate of no use in chronic low back pain.[10] Topiramate has not been shown to work as a pain medicine in diabetic neuropathy, the only neuropathic condition in which it has been adequately tested.[11] Other Off label use for bipolar disorder treatment.[12][13][14] A more recent review, published in 2010, suggested a benefit of topiramate in the treatment of symptoms of borderline personality disorder, however the authors note that this was based only on one randomized controlled trial and requires replication.[15] Topiramate has been used as a treatment for alcoholism.[16] The VA/DoD 2015 guideline on substance use disorders lists topiramate as a "strong for" in its recommendations for alcohol use disorder.[17] Other uses include treatment of obesity[18][19] and antipsychotic-induced weight gain.[20][21] It is being studied to treat post traumatic stress disorder.[22] Phentermine also known as α,α-dimethylphenethylamine, is a psychostimulant drug of the substituted amphetamine chemical class