“Adjunctive estrogen patches significantly improve positive and negative symptoms of schizophrenia in premenopausal women,” research indicates, with the “beneficial effect of the patch” being “especially evident in women older than 38 years.” The findings of the 200-woman, “randomized controlled trial” were published online July 31 in JAMA Psychiatry.
https://www.medscape.com/viewarticle/916820
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