For Those With a Genetic Predisposition to Obesity, Not All Exercise Is Equal

It aimed to investigate gene-exercise interactions on 5 obesity measures: body mass index (BMI), body fat percentage, waist circumference, hip circumference, and waist-to-hip ratio (WHR). A genetic risk score (GRS) was calculated as a weighted sum of risk-allele counts, where the weights were usually derived from large published genome-wide association studies (GWASs) or meta-analyses. Of the exercises examined in the study, regular jogging was the most broadly effective at mitigating the genetic effects on all five obesity measures. When focusing solely on BMI, five other exercises stood out as being beneficial to those predisposed to obesity: mountain climbing, walking, exercise walking, international standard dancing, and a longer practice of yoga. The benefits of regularly performing these six kinds of exercise are more impactful in subjects who are more predisposed to obesity. Exercises such as cycling (989 subjects), stretching exercise (602 subjects), swimming (486 subjects), DDR (420 subjects), and qigong (377 subjects) were more popular or as popular as yoga (379 subjects), but their evidence of interacting with GRS was fairly weak. https://www.technologynetworks.com/genomics/news/for-those-with-a-genetic-predisposition-to-obesity-not-all-exercise-is-equal-322509?utm_campaign=NEWSLETTER_TN_Breaking%20Science%20News&utm_source=hs_email&utm_medium=email&utm_content=75389693&_hsenc=p2ANqtz-9xIg7b0u3APvAoVTr23IGCaLbyXxEkFTyQG9qHELDVYWbYaooNjWvG3ySe_oKFcr1v5RL8KArrzTYUMwBinBMA7BvWzA&_hsmi=75389693