Fluconazole Use May Increase Miscarriage Risk Risks higher than for other antifungals

Use of the oral antifungal medication fluconazole (Difulcan) was associated with increased risk for spontaneous abortion in pregnant women, in comparison with pregnancies in which other antifungals were used as well as those without any such treatment, a large population-based Danish cohort study found. Women who were exposed to oral fluconazole were associated with a significant increased risk of spontaneous abortion versus matched control pregnancies with no record of antifungal use (hazard ratio 1.48, 95% CI 1.23-1.77), reported Ditte Mølgaard-Nielsen, MSc, of Statens Serum Institut in Copenhagen, Denmark, and colleague http://www.medpagetoday.com/OBGYN/Pregnancy/55527?xid=nl_mpt_DHE_2016-01-06&eun=g721819d0r