Fatty Liver Disease Affects Cells' Energy Factories

The insult to ATP producing proteins damaged the mitochondria. In an apparent effort to get rid of dysfunctional mitochondria, cells from fatty livers showed more evidence of digesting their mitochondria, but did not increase production of new ones. As a result, the authors observed mitochondrial and ATP shortages in the cells of mice with fatty liver. The authors proposed that because the overloaded liver cells used fatty acids instead of glucose to make energy, they may have created more reactive oxygen byproducts, which damaged proteins. https://www.technologynetworks.com/proteomics/news/fatty-liver-disease-affects-cells-energy-factories-309574?utm_campaign=Newsletter_TN_BreakingScienceNews&utm_source=hs_email&utm_medium=email&utm_content=65965268&_hsenc=p2ANqtz-_1TpNt2yD7pQ8DE-t7v7bVQBDulWISLitqzP0hZBgFABgTiq0pOEj4yDzSRCFoBbepaRHJAU-LmiyoUKFG9nUiSZSi3w&_hsmi=65965268