Block glucagon for diabetes treatment?

He said appropriate use of glucagon for patients with type 1 diabetes may be in the rescue for hypoglycemic emergencies, use of glucagon inhibition (pramlintide and off-label GLP-1 receptor agonists and DPP-4 inhibitors), and in the bihormonal “bionic” pancreas. Glucagon inhibitory therapy may be suitable for all patients with diabetes, he noted. However, exactly where it will fit in the armamentarium is yet to be determined. Even so, it is hoped that may have the ability to lower diabetes-related morbidity and mortality. For individuals with type 1 diabetes and type 2 diabetes, there is an inappropriate hyperglucagonemia, which is partly responsible for genesis of hyperglycemia in these patients, he explained. Glucagon is a pancreatic hormone that counteracts the glucose-lowering action of insulin by stimulating glycogenolysis and gluconeogenesis. It is a ligand for a specific G-protein linked receptor whose signaling pathway controls cell proliferation and as a medicine, it is different from insulin. Giving a glucagon injection can be intimidating, but it is very important to recognize the symptoms of severe hypoglycemia and be prepared to use glucagon in these emergencies, http://www.endocrinologyadvisor.com/aade-2016/glucagon-for-hypoglycemia-diabetes/article/516180/