Gut Hormones Appear To Mediate Impaired Bone Turnover Markers In NAFLD With Type 2 Diabetes,

“Adults with nonalcoholic fatty liver disease and type 2 diabetes had impaired collagen type 1 C-telopeptide suppression in response to an oral glucose tolerance test but not after an IV glucose infusion, study data show.” Researchers said, “Our findings suggest that NAFLD is a comorbidity that could explain variation in studies regarding bone health in [type 2 diabetes].” They added, “We show that suppression of bone resorption (measured as CTX) is more pronounced when glucose is administered orally vs. intravenously (isoglycemic conditions) in healthy individuals, which supports the role of gut hormones as mediators of postprandial suppression of bone resorption acting either directly or perhaps via gut-mediated increases in insulin secretion.” The findings were published in the Journal of Clinical Endocrinology & Metabolism. https://www.healio.com/endocrinology/bone-mineral-metabolism/news/in-the-journals/%7Be768a255-2f5d-464a-a1e7-b6791bf9c869%7D/gut-hormones-appear-to-mediate-impaired-bone-turnover-markers-in-nafld-with-type-2-diabetes